shinsuke ohba3correspondenceemail, xinjun he3, hironori hojo, andrew p. mcmahon
distinct transcriptional programs underlie sox9 regulation of the mammalian chondrocyte
研究者表示,我们研究揭示了软骨细胞被sox9制造及维持的分子机理,sox9蛋白可以以不同的方式同细胞中的dna结合;在某些情况下,sox9蛋白会成对儿存在,并且在分子修饰器存在的情况下直接同外耳廓按压疼dna结合,当特殊的sox9结合发生在dna上的多个位点时,其就会开启基因的表达使得细胞转变成为软骨细胞
当sox9处于结合的过程中时,其和dna并不会完美地进行结合,而研究者则假设,这种最优的配合或可帮助有效控制软骨细胞中基因所编码的蛋白的水平,因此软骨产生的量或可完全由机体来完成
pmid:
pmc:
sox9 encodes an essential transcriptional regulator of chondrocyte specification and differentiation. when sox9 nuclear activity was compared with markers耳廓疼 of chromatin organization and transcriptional activity in primary chondrocytes, we identified two distinct categories of target association. class i sites cluster around the transcriptional start sites of highly expressed genes with no chondrocyte-specific signature. here, sox9 association reflects 左耳廓软骨膜炎protein-protein association with basal transcriptional components. class ii sites highlight evolutionarily conserved active enhancers that direct chondrocyte-related gene activity through the direct binding of sox9 dimer complexes to dna. sox9 binds through sites with sub-optimal binding affinity; the右耳廓疼 number and grouping of enhancers into super-enhancer clusters likely determines the levels of target gene expression. interestingly, comparison of sox9 action in distinct chondrocyte lineages points to similar regulatory strategies. in addition to providing insights into sox family action, our compr耳廓假囊肿ehensive identification of the chondrocyte regulatory genome will facilitate the study of skeletal development and human disease.
doi:10.1016/j.celrep.2015.06.013
2015年7月6日 讯 /生物谷bioon/ --我们常常认为软骨仅可以帮助确定人体耳朵和鼻子的形状,然而实际上软骨的作用要远大于此,其还可以帮助机体呼吸并且形成健康的骨质,而这两种过程对机体存活至关重要;近日一篇刊登于国际杂志cell reoports上的研究论文中,来自东京大学等处的研究人员通过研究阐明了名为sox耳朵耳廓长了个包9的蛋白质调节软骨产生的分子机制
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最后研究者mcmahon说道,sox9对于全身骨骼的正常发育非常重要,当机体中sox9发生突变时就会发生灾难性的机体病变,比如骨头弯曲以及躯干发育异常等;本文研究揭示了sox9蛋白在机体严重疾病发生过程中所扮演的角色,后期研究者还将通过更深层次的研究来揭示如何利用sox9来开发治疗相关疾病的新型个体化疗法(生物谷bioon.com)
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